Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient
نویسندگان
چکیده
منابع مشابه
Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient.
The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this obs...
متن کاملThe Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized mRNA
The Bicoid morphogen gradient directs the patterning of cell fates along the anterior-posterior axis of the syncytial Drosophila embryo and serves as a paradigm of morphogen-mediated patterning. The simplest models of gradient formation rely on constant protein synthesis and diffusion from anteriorly localized source mRNA, coupled with uniform protein degradation. However, currently such models...
متن کاملMorphogen gradient formation.
How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then...
متن کاملDetermining the scale of the Bicoid morphogen gradient.
Bicoid is a morphogen that sets up the anterior-posterior axis in early Drosophila embryos. Although the form of the Bicoid profile is consistent with a simple diffusion/degradation model, the observed length scale is much larger than should be expected based on the measured diffusion rate. Here, we study two possible mechanisms that could, in principle, affect this gradient and, hence, address...
متن کاملRe-examining the Stability of the Bicoid Morphogen Gradient
In a recent pair of papers published in Cell, Gregor et al. provide an unprecedented glimpse into the dynamics of Bicoid (Bcd), a classical morphogen whose graded distribution along the anterior-posterior axis of the Drosophila embryo provides a key polarity cue guiding embryonic patterning (Gregor et al., 2007a, 2007b). With their data, the authors challenge the prevailing view of how the Bico...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development
سال: 2009
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.031195